Article
Lack of correlation in JNK activation and p53-dependent Fas expression induced by apoptotic stimuli.
Biochemical and biophysical research communications - 24 Mar 1999
Chen Y R, Tan T H
Abstract excerpt
Induction of Fas expression by DNA-damaging agents is dependent on the expression of functional p53, and has been suggested to play an important role in apoptosis induction. JNK (c-Jun N-terminal kinase), which is capable of phosphorylating p53, is also involved in apoptotic signaling induced by various apoptotic stimuli. Here, we report that although Fas induction is closely linked to the expression of wild type...
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