Article
Dual-priming oligonucleotide-based multiplex PCR for the detection of Helicobacter pylori and determination of clarithromycin resistance with gastric biopsy specimens.
Helicobacter - 1 Feb 2009
Woo Hee-Yeon, Park Dong Il, Park Hyosoon, Kim Min-Kyung, Kim Dong Hoon, Kim In-Suk, Kim Young Jae
Abstract excerpt
BACKGROUND: Assessment of Helicobacter pylori (H. pylori) clarithromycin resistance has rarely been performed routinely despite an increasing resistance rate. Our aim was to develop and evaluate the use of dual-priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) to detect point mutations in the 23S rRNA gene responsible for clarithromycin resistance of H. pylori. MATERIALS AND METHODS:...
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