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Article

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation.

Current opinion in genetics & development - 1 Feb 1999

Dennis P B, Fumagalli S, Thomas G

Abstract excerpt

Mitogenic and nutritional signals must be integrated for a cell to grow. The target of rapamycin (TOR) is emerging as an effector for signals which indicate to the cell whether the external environment is conducive for growth. Use of the immunosuppressant rapamycin, a bacterial macrolide, has been instructive in identifying potential signaling components downstream of TOR, leading to the observation that both...

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Identifiers

PMID: 10072357
DOI: 10.1016/s0959-437x(99)80007-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation.PMID 10072357Read ↗

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Identification of TOR signaling complexes: more TORC for the cell growth engine.Semantic proximity Read ↗

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Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chipsSemantic proximity Read ↗

The TOR signaling cascade regulates gene expression in response to nutrients.Semantic proximity Read ↗

The Role of mTOR Signaling in Controlling Mammalian Life Span: What a Fungicide Teaches Us About LongevitySemantic proximity Read ↗

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