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Article

Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII.

The Journal of biological chemistry - 5 Mar 1999

Edwards A S, Faux M C, Scott J D, Newton A C

Abstract excerpt

Protein kinase C is processed by three phosphorylation events before it is competent to respond to second messengers. Specifically, the enzyme is first phosphorylated at the activation loop by another kinase, followed by two ordered autophosphorylations at the carboxyl terminus (Keranen, L. M., Dutil, E. M., and Newton, A. C. (1995) Curr. Biol. 5, 1394-1403). This study examines the role of negative charge at the...

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Identifiers

PMID: 10037738
DOI: 10.1074/jbc.274.10.6461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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