Article
Molecular genetic analysis of enoyl-acyl carrier protein reductase inhibition by diazaborine.
Molecular microbiology - 1 Jan 1999
de Boer G J, Pielage G J, Nijkamp H J, Slabas A R, Rafferty J B, Baldock C, Rice D W, Stuitje A R
Abstract excerpt
Diazaborine and isoniazid are, at first sight, unrelated anti-bacterial agents that inhibit the enoyl-ACP reductase (ENR) of Escherichia coli and Mycobacterium tuberculosis respectively. The crystal structures of these enzymes including that of the diazaborine-inhibited E. coli ENR have been obtained at high resolution. Site-directed mutagenesis was used to study the importance of amino acid residues in...
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