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Article

Structural basis of triclosan resistance.

Journal of structural biology - 1 Apr 2011

Singh N Jiten, Shin Dongkyu, Lee Han Myoung, Kim Hyun Tae, Chang Ho-Jin, Cho Joong Myung, Kim Kwang S, Ro Seonggu

Abstract excerpt

Triclosan (5-chloro-2-(2,4-dichloro-phenoxy)-phenol, TCL) is a well known inhibitor against enoyl-acyl carrier protein reductase (ENR), an enzyme critical for cell-wall synthesis of bacteria. The inhibitory concentration at 50% inhibition (IC(50)) of TCL against the Escherichia coli ENR is 150nM for wild type (WT), 380, 470 and 68,500nM for Ala, Ser and Val mutants, respectively. To understand this high TCL...

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Identifiers

PMID: 21094257
DOI: 10.1016/j.jsb.2010.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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