Article
Folate status, homocysteine metabolism, and methylene tetrahydrofolate reductase genotype in rural South African blacks with a history of pregnancy complicated by neural tube defects.
Metabolism: clinical and experimental - 1 Feb 1999
Ubbink J B, Christianson A, Bester M J, Van Allen M I, Venter P A, Delport R, Blom H J, van der Merwe A, Potgieter H, Vermaak W J
Abstract excerpt
The birth incidence of neural tube defects (NTDs) in South Africa is threefold to sixfold higher in rural compared with urban blacks. We investigated whether folate deficiency and aberrant homocysteine metabolism could explain the high NTD incidence in rural black populations. Plasma folate and total homocyst(e)ine (tHcy) concentrations were determined in apparently healthy rural black women (n = 107), rural...
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