Article
No evidence of p53 allele-specific predisposition in human papillomavirus-associated cervical cancer.
Journal of molecular medicine (Berlin, Germany) - 1 Feb 1999
Klaes R, Ridder R, Schaefer U, Benner A, von Knebel Doeberitz M
Abstract excerpt
The potential association of distinct polymorphisms of the tumor suppressor gene p53 with an increased susceptibility to malignant transformation has been reported for various cancer entities. Most recently, p53 protein containing an arginine residue in codon 72 was shown to be more effectively degraded by the E6 oncoprotein of human papillomavirus (HPV) than the corresponding proline isoform in cervical...
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