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Article

Correlation between human papillomavirus-associated cervical cancer and p53 codon 72 arginine/proline polymorphism.

Human genetics - 1 Dec 1999

Tachezy R, Mikysková I, Saláková M, Van Ranst M

Abstract excerpt

High-risk mucosal human papillomaviruses encode an E6 oncoprotein, which binds the cellular p53 tumor suppressor protein, thereby marking it for degradation through the ubiquitin-mediated pathway. A common p53 polymorphism at codon-72 of exon 4 results in translation to either arginine or proline. Recently reported data suggested an increased susceptibility to E6/ubiquitin-mediated degradation of the Arg72-p53...

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Identifiers

PMID: 10647890
DOI: 10.1007/s004399900138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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