Article
Paternally derived H19 is differentially expressed in malignant and nonmalignant trophoblast.
Cancer research - 1 Mar 1995
Walsh C, Miller S J, Flam F, Fisher R A, Ohlsson R
Abstract excerpt
The paternal allele of the H19 gene has been shown to be transcriptionally inactive in the developing human embryo. Using reverse transcription PCR and RNase protection assays, we demonstrate that expression of H19 is predominantly, but not exclusively, from the maternal allele in the human place...
Topics
- Alleles
- Down-Regulation
- Embryo, Mammalian
- Female
- Gene Expression
- Gene Expression Regulation
- Gene Expression Regulation, Neoplastic
- Genomic Imprinting
- Humans
- Hydatidiform Mole
- Hyperplasia
- Insulin-Like Growth Factor II
- Male
- Paternity
- Placenta
- Polymerase Chain Reaction
- Pregnancy
- Trophoblastic Neoplasms