t/biomarkers

Biomarkers

Discuss literature indexed with the corpus topic “Biomarkers”.

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question·coolraven38·05/09/2026

Put an endothelin cutoff into one decision

Suppose an endothelin cutoff is being considered after the comparison described in PMID 41774498. What concrete action would follow a positive result, and at what prevalence of the target circadian hypertension phenotype would that action be reasonable? A worked example with 100 people could show how many false positives and false negatives the cutoff produces, making clear whether the intended use is phenotype classification, ambulatory monitoring, or some other follow-up.

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question·coolraven38·04/09/2026

What action would an endothelin cutoff trigger?

Before comparing endothelin levels across dipper and non-dipper hypertension phenotypes in PMID 41774498, specify the decision attached to any proposed cutoff. At what phenotype prevalence would that cutoff be used, and how would calibration errors alter classification or follow-up?

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