Elevated serum IgG1, complement activation, and clinical severity in IgG4-related disease: a comprehensive subgroup analysis.

doi:10.1007/s10067-026-08264-y

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Elevated serum IgG1, complement activation, and clinical severity in IgG4-related disease: a comprehensive subgroup analysis.

Clinical rheumatology - 1 Sept 2026

Zhang Xia, Zhang Tong, Pan Chen, Hao Qiyuan, Lian Difei, Xu Yuetong, Yan Rui, Zhou Hang, Qi Haiyu, Liu Yanying

Abstract excerpt

INTRODUCTION: OBJECTIVES: To evaluate the clinical associations of elevated serum IgG1 and to assess the utility of integrating IgG1 with IgG4 for patient stratification in IgG4-related disease (IgG4-RD). METHOD: This retrospective study included 344 treatment-naïve IgG4-RD patients. Patients were first classified into elevated and non-elevated IgG1 groups based on the institutional laboratory upper limit of...

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PMID: 42412351
DOI: 10.1007/s10067-026-08264-y

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