Unsupervised machine learning derived bone phenotypes exhibit differential biomarker responses following acute ballistic loaded exercise.

doi:10.1016/j.bone.2026.118013

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Article

Unsupervised machine learning derived bone phenotypes exhibit differential biomarker responses following acute ballistic loaded exercise.

Bone - 1 Nov 2026

Goulart Jenna B, Kargl Christopher K, Sterczala Adam J, Sekel Nicole M, Mroz Kelly H, Lovalekar Mita, Fazeli Pouneh K, Bolger Morgan W, Cauley Jane A, Hubal Monica J, Ambrosio Fabrisia, Martin Brian J, Bean Allison C, O'Leary Thomas J, Greeves Julie P, Koltun Kristen J, Nindl Bradley C

Abstract excerpt

Resistance exercise can stimulate new bone formation and result in changes to circulating markers of bone metabolism, but the relationship between the bone metabolic response to resistance exercise and bone morphological phenotypes is unknown. This study compared circulating bone biomarker responses to acute ballistic resistance exercise between groups characterized by bone phenotypes. Fuzzy c-means clustering...

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PMID: 42435954
DOI: 10.1016/j.bone.2026.118013

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