Article

Two-hit events occurred independently in bilateral breast cancer of a heterozygous double germline pathogenic variants carrier of BRCA1 and BRCA2

2025-04-01

Abstract excerpt

<title>Abstract</title> <p>While patients with hereditary breast and ovarian cancer with both <italic>BRCA1</italic> and <italic>BRCA2</italic> germline pathogenic variants (PVs) are rare, carcinogenesis in these cases remains unclear. We examined two-hit events of heterochronous bilateral breast cancers in a patient with <italic>BRCA1</italic> and <italic>2</italic> PVs. A 65-year-old woman developed right breas...

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Literature Corpus work: ff8d8be6-26d3-5799-8272-345e1358f25a
DOI: 10.21203/rs.3.rs-6272927/v1

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