Impact of Light Chain Variants on the Expression of Therapeutic Monoclonal Antibodies in HEK293 and CHO Cells

Abstract excerpt

Recombinantly produced monoclonal antibodies (mabs) belong to the fastest growing class of biotherapeutics. In humans, antibodies are classified into five different classes: IgA, IgD, IgE, IgG and IgM. Most of the therapeutic mabs used in the clinic belong to the IgG class, albeit other antibody-classes, e.g. IgM, have been evaluated in clinical stages. Antibodies are composed of heavy chains paired with a light c...

Topics

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• Antibodies, Bispecific
• Antibodies, Monoclonal
• Clinical Trials as Topic
• Combinatorial Chemistry Techniques
• HER2/EGFR in Cancer Research
• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

fe1f139e-19d0-50a6-b641-d659bc5c9b8a

DOI

10.20944/preprints202505.1816.v1