Article

Comparative Transcriptomics Reveals Inflammatory and Epigenetic Programs that Actively Orchestrate Pineal Brain Sand Calcification

2025-06-20

Abstract excerpt

<h4>Background</h4> The pineal gland secretes melatonin but paradoxically calcifies more than any other intracranial structure, forming hydroxyapatite “brain-sand” (corpora arenacea) that correlates with reduced melatonin output, sleep disruption and heightened neuro-degenerative risk. Whether this mineralization is a passive dystrophic event or an active, bone-like process remains unclear. <h4>Methods</h4> Anal...

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Literature Corpus work: fdeb9f2c-2d74-5fa3-a081-5d576c3a307c
DOI: 10.1101/2025.06.16.660032

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