Article

Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe for neurodegenerative diseases

2025-02-13

Abstract excerpt

<h4>Background</h4> The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimer’s disease (AD) and Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) indicating a potential for metrics from this region to serve as imaging biomarkers. Leveraging a unique post-mortem dataset of histology and magnetic resonance imaging (MRI) scans we aimed t...

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Literature Corpus work: fd3baa3f-181b-5079-a566-257e615febed
DOI: 10.1101/2025.02.11.637506

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