Article

ANGPTL3 Gene Variants in Subjects With Familial Combined Hyperlipidemia

2021-01-04

Abstract excerpt

Angiopoietin-like 3 (ANGPTL3) plays an important role in lipid metabolism in humans. Loss-of-function variants in ANGPTL3 cause a monogenic disease named familial combined hypolipidemia. However, the potential contribution of ANGPTL3 gene in subjects with familial combined hyperlipidemia (FCHL) has not been studied. To study the gain-of-function (GOF) genetic variants in the ANGPTL3 gene in FCHL subjects and to es...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd30bafc-1441-5f61-96cf-17baa30c034c
DOI: 10.21203/rs.3.rs-134198/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ANGPTL3 Gene Variants in Subjects With Familial Combined HyperlipidemiaDOI 10.21203/rs.3.rs-134198/v1Read

ANGPTL3 gene variants in subjects with familial combined hyperlipidemia.Semantic proximity Read

Exome Sequencing,<i>ANGPTL3</i>Mutations, and Familial Combined HypolipidemiaSemantic proximity Read

Molecular mechanisms, prevalence, and molecular methods for familial combined hyperlipidemia disease: A reviewSemantic proximity Read

Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined HypocholesterolemiaSemantic proximity Read

Prevalence of ANGPTL3 and APOB gene mutations in subjects with combined hypolipidemia.Semantic proximity Read

Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis.Semantic proximity Read

Genetics of familial combined hyperlipidemia.Semantic proximity Read

Familial combined hyperlipidemia: An overview of the underlying molecular mechanisms and therapeutic strategiesSemantic proximity Read

ANGPTL3 serum concentration and rare genetic variants in Finnish population.Semantic proximity Read

Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization.Semantic proximity Read

Characterization of three kindreds with familial combined hypolipidemia caused by loss-of-function mutations of ANGPTL3.Semantic proximity Read

Six years' experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias.Semantic proximity Read