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Article

Additive association of blood group A allele with 15 cardiometabolic diseases: a UK Biobank life-course study.

Cardiovascular diabetology - 10 Mar 2025

Zhao Ran, Xian Wenyan, Ma Yihao, Napolioni Valerio, Lau Patrick W C, Tian Xiao-Li, Le Guen Yann, Franke Andre, Huang Jie

Abstract excerpt

BACKGROUND: Although existing studies have reported associations between blood group A and cardiometabolic diseases (CMD), most have focused on dominant inheritance models. However, genome-wide association studies have mostly been based on additive genotypes. This study aims to investigate the association between the blood group A allele and 15 CMD using recessive, dominant, and additive models and identify...

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Identifiers

PMID: 40065387
DOI: 10.1186/s12933-025-02669-w
PMCID: PMC11895148

Genes

ABO
CAD

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