Article

Saliva from Oral Squamous Cell Carcinoma Patients Promotes Tumor Progression via Inflammation, Stromal Remodeling, and Metabolic Reprogramming in a Mouse Model

2025-11-04

Abstract excerpt

<title>Abstract</title> <p> Background Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive malignancy with increasing evidence implicating the oral microbiome and tumor microenvironment in its progression. However, the mechanistic impact of OSCC patient-derived saliva on tumor development remains poorly understood. Methods We established an orthotopic OSCC mouse model and topically applied saliva c...

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Literature Corpus work: fb419cf9-ff3b-5dcc-8181-bc98b2de17d9
DOI: 10.21203/rs.3.rs-7610282/v1

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