Article

Divergent cancer etiologies drive distinct B cell signatures and tertiary lymphoid structures

2020-05-31

Abstract excerpt

Current immunotherapy paradigms aim to reinvigorate CD8 + T cells, but the contribution of humoral immunity to antitumor immunity remains understudied 1,2 . Head and neck squamous cell carcinoma (HNSCC) is caused by either human papillomavirus (HPV+) or environmental carcinogens (i.e. tobacco and alcohol; HPV–) 3,4 . Here, we demonstrate that HPV+ HNSCC patients have transcriptional signatures of germinal cente...

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Literature Corpus work: fb214e03-9ee1-5ca5-9ff2-65a6aa9f3dba
DOI: 10.1101/2020.05.29.123265

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