Article

Client processing is altered by novel myopathy-causing mutations in the HSP40 J domain

2020-02-14

Abstract excerpt

The misfolding and aggregation of proteins is often implicated in the development and progression of degenerative diseases. Heat shock proteins (HSPs), such as the ubiquitously expressed Type II Hsp40 molecular chaperone, DNAJB6, assist in protein folding and disaggregation. Historically, mutations within the DNAJB6 G/F domain have been associated with Limb-Girdle Muscular Dystrophy type 1D, now referred to as LGM...

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Literature Corpus work: fae3d852-a34a-5dce-9388-23ff414d5c99
DOI: 10.1101/2020.02.14.949792

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