Article

Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy

2020-01-03

Abstract excerpt

Dominant mutations in the HSP70 co-chaperone DNAJB6 cause a late onset muscle disease termed limb girdle muscular dystrophy type 1D (LGMD1D), which is characterized by protein aggregation and vacuolar myopathology. Disease mutations reside within the G/F domain of DNAJB6, but the molecular mechanisms underlying dysfunction are not well understood. Using yeast, cell culture, and mouse models of LGMD1D, we find that...

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Literature Corpus work: 0a6d6ff4-1208-58ab-8851-66cb331fe7bf
DOI: 10.1101/2020.01.03.893149

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