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Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy

19 May 2020

Abstract excerpt

Dominant mutations in the HSP70 cochaperone DNAJB6 cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology. Disease mutations reside within the G/F domain of DNAJB6, but the molecular mechanisms underlying dysfunction are not well understood. Using yeast, cell culture, and mouse models of LGMDD1, we found...

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PMID: 32427588
DOI: 10.1172/jci136167

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