Article

Gene-interaction perturbation network analysis identifies distinct subtypes and actionable targets for aggressive thyroid cancer: an integrative multi-omics and machine learning approach for precise medicine

2025-10-30

Abstract excerpt

<title>Abstract</title> <p>High-risk thyroid cancer such as aggressive papillary thyroid cancer (PTC) and anaplastic thyroid cancer (ATC) poses significant clinical challenges due to their tumor heterogeneity and limited therapeutic strategies. We constructed a genetic interaction (GI) perturbation network based on functional interactions from the Reactome database and identified distinct molecular subtypes of th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa1700b9-050a-5f42-aeff-85befec0c916
DOI: 10.21203/rs.3.rs-7834338/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene-interaction perturbation network analysis identifies distinct subtypes and actionable targets for aggressive thyroid cancer: an integrative multi-omics and machine learning approach for precise medicineDOI 10.21203/rs.3.rs-7834338/v1Read

Integrated proteogenomic and metabolomic characterization of papillary thyroid cancer with different recurrence risksSemantic proximity Read

Integration of mult-omics and nucleotide metabolism reprogramming signature analysis reveals gastric cancer immunological and prognostic featuresSemantic proximity Read

Integrated analysis of tumor microenvironment features to establish a diagnostic model for papillary thyroid cancer by using bulk and single-cell RNA sequencing technologySemantic proximity Read

Integrated Proteomics and Transcriptomics Identify a FN1-ANXA1-PTK2B Network Driving Lymph Node Metastasis in Papillary Thyroid CarcinomaSemantic proximity Read

Multi-omics Signatures and Translational Potential to Improve Thyroid Cancer Patient OutcomeSemantic proximity Read

Recent Improvements in Genomic and Transcriptomic Understanding of Anaplastic and Poorly Differentiated Thyroid Cancers.Semantic proximity Read

Integrated proteogenomic and metabolomic characterization of papillary thyroid cancer with different recurrence risksSemantic proximity Read

Thyroid carcinoma: molecular pathways and therapeutic targetsSemantic proximity Read

Advances and challenges in thyroid cancer: The interplay of genetic modulators, targeted therapies, and AI-driven approachesSemantic proximity Read

Genomics and Multi-Omics to Guide Clinical Management in Thyroid CancerSemantic proximity Read

Mining Prognostic Significance Genes in Human Thyroid Cancer Using Bioinformatics AnalysisSemantic proximity Read

The Integrated Analyses of Driver Genes Identify Key Biomarkers in Thyroid Cancer.Semantic proximity Read