Article
Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2013
Liu Fei, Fang Fang, Yuan Hebao, Yang Dongye, Chen Yongqiang, Williams Linford, Goldstein Steven A, Krebsbach Paul H, Guan Jun-Lin
Abstract excerpt
Autophagy is a conserved lysosomal degradation process that has important roles in both normal human physiology and disease. However, the function of autophagy in bone homeostasis is not well understood. Here, we report that autophagy is activated during osteoblast differentiation. Ablation of focal adhesion kinase family interacting protein of 200 kD (FIP200), an essential component of mammalian autophagy, led...
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