Article

Development of a highly sensitive immunoassay to measure ataxin2 as a target engagement marker in Spinocerebellar Ataxia Type 2

2022-10-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Spinocerebellar Ataxia Type 2 (SCA2) belongs to a group of neurodegenerative diseases, inherited as an autosomal dominant trait. SCA2 is a trinucleotide repeat disease with a CAG repeat expansion in exon 1 of the <italic>ATXN2</italic>gene resulting in an ataxin-2 protein with an expanded polyglutamine (polyQ)-stretch. The disease is late manifesting leading to p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f9b15db8-8163-557c-a5a2-5d61285453ed
DOI: 10.21203/rs.3.rs-2144417/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of a highly sensitive immunoassay to measure ataxin2 as a target engagement marker in Spinocerebellar Ataxia Type 2DOI 10.21203/rs.3.rs-2144417/v1Read

Polyglutamine-expanded ataxin-3: a target engagement marker for Spinocerebellar ataxia type 3 in peripheral bloodSemantic proximity Read

Polyglutamine‐Expanded Ataxin‐3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral BloodSemantic proximity Read

Ataxin-2 Binds Alpha-Actinin-1Semantic proximity Read

Ataxin-2 gene: a powerful modulator of neurological disordersSemantic proximity Read

New alternative splicing variants of the ATXN2 transcriptSemantic proximity Read

Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 diseaseSemantic proximity Read

Small molecule v-ATPase inhibitor Etidronate lowers levels of ALS protein ataxin-2Semantic proximity Read

Immuno-based detection assays to quantify distinct mutant huntingtin conformations in biological samples.Semantic proximity Read

Quantitative profiling and identification of plasma proteins of spinocerebellar ataxia type 2 patients.Semantic proximity Read

Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2Semantic proximity Read

Recent Advances on Affibody- and DARPin-Conjugated Nanomaterials in Cancer TherapySemantic proximity Read

Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 diseaseSemantic proximity Read