Article

Vitamin D Hypersensitivity as a Potential Trigger for Worsening Vascular Calcification: A Hypothesis

2026-06-23

Abstract excerpt

Observational studies have consistently associated low serum 25-hydroxyvitamin D [25(OH)D₃] levels with an increased risk of cardiovascular disease, but large randomized trials and Mendelian randomization studies have failed to demonstrate a causal relationship. We propose that this paradox is partly explained by the considerable interindividual variability in vitamin D (VD) response. In individuals with VD hypers...

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Literature Corpus work: f973d269-f7b7-5115-81a4-6f7369c9d015
DOI: 10.20944/preprints202601.1504.v2

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