Article

High prevalence of deleterious germline variants in cancer risk genes among subjects with young-onset, sporadic pituitary macroadenomas

2025-05-16

Abstract excerpt

<h4>Introduction</h4> Pituitary adenomas/pituitary neuroendocrine tumors (PitNETs) are common intracranial tumors, clinically affecting 1:1000 individuals and most cases remain genetically unexplained. Emerging research has highlighted the major contribution of germline pathogenic variants to tumorigenesis across many tissue types in young subjects . We investigated whether young-onset (<30 years old) pituitary ma...

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Literature Corpus work: f925426a-9bef-5c1b-8a49-21cdcdb69ecb
DOI: 10.1101/2025.05.15.25327006

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