Article

A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

2019-04-22

Abstract excerpt

Mutations in the gene AK2 are responsible for Reticular Dysgenesis (RD), a rare and severe form of primary immunodeficiency in children. RD patients have a severely shortened life expectancy and without treatment die a few weeks after birth. The only available therapeutic option for RD is bone marrow transplantation. To gain insight into the pathophysiology of RD, we previously created zebrafish models for an AK2...

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Literature Corpus work: aa620a01-3f27-5d6d-adfc-0ccd36286ad7
DOI: 10.1101/610204

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