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Epistasis between synonymous and nonsynonymous mutations in <i>Dictyostelium discoideum</i> ammonium transporter <i>amtA</i> drives functional complementation in <i>Saccharomyces cerevisiae</i>

2022-04-08

Abstract excerpt

Role of H orizontal G ene T ransfer (HGT) in evolution transcends across the three domains of life. Ammonium transporters are present in all species and therefore offer an excellent paradigm to study protein evolution following HGT. While investigating HGT through complementation assay, we observed that synonymous and nonsynonymous mutations follow an epistastic relationship. As a proxy for HGT, we attempted to...

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Literature Corpus work
f805739b-beca-500e-87a8-1832adea8e78
DOI
10.1101/2022.04.05.486919
Open publication

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Epistasis between synonymous and nonsynonymous mutations in <i>Dictyostelium discoideum</i> ammonium transporter <i>amtA</i> drives functional complementation in <i>Saccharomyces cerevisiae</i>DOI 10.1101/2022.04.05.486919
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