Article

Integrating GEO Database and Bioinformatics Analysis to Screen the Key Targets of Tanshinone IIA in Myocardial Infarction

2025-11-25

Abstract excerpt

<title>Abstract</title> <p> <bold>Objective:</bold> To systematically screen the core targets of Tanshinone IIA in the treatment of myocardial infarction (MI) and to explore its molecular mechanisms based on the Gene Expression Omnibus (GEO) database and bioinformatics methods. <bold>Methods:</bold> MI-related transcriptome datasets (GSE62646, GSE83500) were obtained from the GEO database. The "sva" package w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7cfee08-36f6-5c1e-88c4-14133a814cf4
DOI: 10.21203/rs.3.rs-8185303/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrating GEO Database and Bioinformatics Analysis to Screen the Key Targets of Tanshinone IIA in Myocardial InfarctionDOI 10.21203/rs.3.rs-8185303/v1Read

Intervention of Tanshinone IIA on the PGK1-PDHK1 Pathway to Reprogram Macrophage Phenotype After Myocardial Infarction.Semantic proximity Read

Exploration of the molecular targets and mechanisms of suxiao xintong dropping pills for myocardial infarction by network pharmacology methodSemantic proximity Read

Network Pharmacology to Explore Active Components and Pharmacological Mechanism of Action of Compound Longmai Ning Decoction for the Treatment of Myocardial InfarctionSemantic proximity Read

Integrated network pharmacology to investigate the mechanism of Salvia miltiorrhiza Bunge in the treatment of myocardial infarctionSemantic proximity Read

Research on the Mechanism of Wuwei Yuganzi San in the Treatment of Coronary Heart Disease Based on Network PharmacologySemantic proximity Read

Study on biological impacts of Xuefu Zhuyu Decoction in the treatment of coronary heart disease through Investigating target genes and molecular dockingSemantic proximity Read

Mechanism of Action of Nicotiflorin from Tricyrtis maculata in the Treatment of Acute Myocardial Infarction: From Network Pharmacology to Experimental PharmacologySemantic proximity Read

Network pharmacology and molecular docking in the exploration of Taohong Siwu decoction against coronary heart diseaseSemantic proximity Read

Identifying key genes associated with acute myocardial infarctionSemantic proximity Read

Systematic Pharmacology and GEO Database Mining Revealed the Mechanism of XFZYD Therapy for ASCVDSemantic proximity Read

Unveiling the Molecular Mechanisms and Active Components of Angong Niuhuang Pills in Stroke Treatment: Network Pharmacology, Molecular Docking, and Cellular StudiesSemantic proximity Read

KAT2A-targeted inhibition prevents an inflammatory response to protect the myocardiumSemantic proximity Read