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Lidocaine Modulates Cytokine Production and Enhances Anti-Tumor Immune Response in Gastric Cancer: Dual Effects on Normal Peripheral Blood Mononuclear Cells and Primary Gastric Tumor-Infiltrating Immune Cells

2024-10-11

Abstract excerpt

Lidocaine, a commonly used local anesthetic, has demonstrated modulatory effects in various cells. This study investigates the impact of lidocaine on cytokine production in peripheral blood mononuclear cells (PBMCs) from healthy donors and tumor-infiltrating immune cells (TIICs) from gastric cancer patients. Flow cytometry and cytokine assays revealed that lidocaine inhibited IFN-γ and IL-12 production in CD8+ and...

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Literature Corpus work
f75b780d-3ef7-5d3c-a062-191a5c02e584
DOI
10.20944/preprints202410.0881.v1
Open publication

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Lidocaine Modulates Cytokine Production and Enhances Anti-Tumor Immune Response in Gastric Cancer: Dual Effects on Normal Peripheral Blood Mononuclear Cells and Primary Gastric Tumor-Infiltrating Immune CellsDOI 10.20944/preprints202410.0881.v1
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