Article

Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheep

2022-12-12

Abstract excerpt

Antigen-specific polyclonal immunoglobulins derived from the serum, colostrum, or milk of immunized ruminant animals have potential as scalable therapeutics for the control of viral diseases such as COVID-19. Enhancing the efficacy of vaccine antigens to induce robust and specific antibody responses remains central to developing highly effective formulations. The direct fusion of immunoglobulin (IgG) Fc domains or...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f73aa87d-890c-5011-867c-6d2d667084a2
DOI: 10.1101/2022.12.11.519990

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheepDOI 10.1101/2022.12.11.519990Read

Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprintingSemantic proximity Read

Characteristics and functions of infection-enhancing antibodies to the N-terminal domain of SARS-CoV-2Semantic proximity Read

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 VariantsSemantic proximity Read

A comprehensive antigen production and characterization study for easy-to-implement, highly specific and quantitative SARS-CoV-2 antibody assaysSemantic proximity Read

Functional Antibodies Against SARS-CoV-2 Receptor Binding Domain Variants with Mutations N501Y or E484K in Human Milk from COVID-19-Vaccinated, -Recovered, and -Unvaccinated Women.Semantic proximity Read

Robust correlations across six SARS‐CoV‐2 serology assays detecting distinct antibody featuresSemantic proximity Read

A Recombinant Protein SARS-CoV-2 Candidate Vaccine Elicits High-titer Neutralizing Antibodies in Macaques.Semantic proximity Read

The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patientsSemantic proximity Read

The RBD Of The Spike Protein Of SARS-Group Coronaviruses Is A Highly Specific Target Of SARS-CoV-2 Antibodies But Not Other Pathogenic Human and Animal Coronavirus AntibodiesSemantic proximity Read

Fc-engineered antibody therapeutics with improved efficacy against COVID-19Semantic proximity Read

SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patientsSemantic proximity Read

Detection and Quantification of Antibody to SARS-CoV-2 Receptor Binding Domain Provides Enhanced Sensitivity, Specificity and UtilitySemantic proximity Read