Article

<i>Straightjacket/α2δ3</i> deregulation is associated with cardiac conduction defects in Myotonic Dystrophy type 1

2018-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Cardiac conduction defects decrease life expectancy in myotonic dystrophy type 1 (DM1), a complex toxic CTG repeat disorder involving misbalance between two RNA- binding factors, MBNL1 and CELF1. How this pathogenic DM1 condition translates into cardiac conduction disorders remains poorly understood. Here, we simulated MBNL1 and CELF1 misbalance in the Drosophila heart and identified associated...

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Literature Corpus work: f700c24e-f91b-5ddc-a1f0-4e277a89a397
DOI: 10.1101/431569

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