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Pilot assessment of low NK cell-mediated ADCC and<i>FCGR3A</i>genetics in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Based on inclusion of family members without ME/CFS as controls, low ADCC is unsuitable as a diagnostic biomarker

2019-12-27

Abstract excerpt

ADCC (antibody-dependent cell-mediated cytotoxicity) is dependent on the varying capacity of NK cells to kill, the affinities of FCGR3A -encoded CD16A receptors for antibody, and the presence of antigen-specific antibodies. In vivo ADCC depends on the number of CD16A receptor-positive NK cells in blood. We hypothesized that low ADCC cell function or low effector cell numbers could be biomarkers or risk factors for...

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Literature Corpus work
f6de2c3a-fbdf-5b6a-8964-cef83be426c6
DOI
10.1101/2019.12.20.19015438
Open publication

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Pilot assessment of low NK cell-mediated ADCC and<i>FCGR3A</i>genetics in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Based on inclusion of family members without ME/CFS as controls, low ADCC is unsuitable as a diagnostic biomarkerDOI 10.1101/2019.12.20.19015438
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