Article
Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients.
The Journal of international medical research - 1 Dec 2016
Marshall-Gradisnik Sonya, Johnston Samantha, Chacko Anu, Nguyen Thao, Smith Peter, Staines Donald
Abstract excerpt
Objective The pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is unknown; however, a small subgroup of patients has shown muscarinic antibody positivity and reduced symptom presentation following anti-CD20 intervention. Given the important roles of calcium (Ca2+) and acetylcholine (ACh) signalling in B cell activation and potential antibody development, we aimed to identify relevant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.