Article

DRED: A Comprehensive Database of Genes Related to Repeat Expansion Diseases

2024-09-13

Abstract excerpt

Expansion of tandem repeats in genes often causes severe neuromuscular diseases, such as fragile X syndrome, huntington’s disease, and spinocerebellar ataxia. However, information on genes associated with repeat expansion diseases is scattered throughout the literature, systematic prediction of potential genes that may cause diseases via repeat expansion is also lacking. Here, we develop DRED, a Database of genes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6c53f47-83c3-5740-8f45-dcdfb98fd9e2
DOI: 10.1101/2024.09.07.611652

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DRED: A Comprehensive Database of Genes Related to Repeat Expansion DiseasesDOI 10.1101/2024.09.07.611652Read

A genome-wide approach for the discovery of novel repeat expansion disorders in the Undiagnosed Diseases Network cohort.Semantic proximity Read

Identification and characterization of repeat expansions in neurological disorders: Methodologies, tools, and strategiesSemantic proximity Read

Expanded complexity of unstable repeat diseases.Semantic proximity Read

Trinucleotide repeats: mechanisms and pathophysiology.Semantic proximity Read

Repeat expansion disordersSemantic proximity Read

Profiling human pathogenic repeat expansion regions by synergistic and multi-level impacts on molecular connectionsSemantic proximity Read

Microsatellite expansions hidden within the human dark genome are translated in novel and toxic proteins causing muscle and neurodegenerative diseasesSemantic proximity Read

Polymorphic CGG repeats in gene regulation and disease.Semantic proximity Read

Computational and experimental hunt for expansion prone tandem CNG repeats in human genomesSemantic proximity Read

Recent advances in CGG repeat diseases and a proposal of fragile X-associated tremor/ataxia syndrome, neuronal intranuclear inclusion disease, and oculophryngodistal myopathy (FNOP) spectrum disorderSemantic proximity Read

Fourteen and counting: unraveling trinucleotide repeat diseasesSemantic proximity Read

Population Frequency of Repeat Expansions Indicates Increased Disease Prevalence Estimates Across Different PopulationsSemantic proximity Read