Article

Cross-talk between SIM2s and NFkB regulates cyclooxygenase 2 expression in breast cancer

2019-05-10

Abstract excerpt

<h4>Background</h4> Breast cancer is a leading cause of cancer-related death for women in the United States. Thus, there a need to investigate novel prognostic markers and therapeutic strategies. Inflammation raises challenges to both treating and preventing the spread of breast cancer. Specifically, the nuclear factor kappa b (NFkB) pathway contributes to cancer progression by stimulating proliferation and preve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6b1a949-fdfc-5981-9fc4-5842bf7bfdd3
DOI: 10.1101/634113

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross-talk between SIM2s and NFkB regulates cyclooxygenase 2 expression in breast cancerDOI 10.1101/634113Read

Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer.Semantic proximity Read

Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancersSemantic proximity Read

Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity.Semantic proximity Read

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast CancerSemantic proximity Read

Inhibition of breast cancer growth and invasion by single-minded 2sSemantic proximity Read

DDB2: A Novel Regulator of NF-κB and Breast Tumor InvasionSemantic proximity Read

ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancerSemantic proximity Read

COX-2 induces oncogenic micro RNA miR655 in human breast cancer.Semantic proximity Read

S-Nitrosylated COX-2 is a TME-regulated breast cancer biomarker of mesenchymal phenotypesSemantic proximity Read

Inhibiting NFAT1 for breast cancer therapy: New insights into the mechanism of action of MDM2 inhibitor JapASemantic proximity Read

The breast cancer susceptibility gene product fibroblast growth factor receptor 2 serves as a scaffold for regulation of NF-κB signaling.Semantic proximity Read

The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer CellsSemantic proximity Read