Article
Sputum DNA sequencing in cystic fibrosis: non-invasive access to the lung microbiome and to pathogen details.
Microbiome - 10 Feb 2017
Feigelman Rounak, Kahlert Christian R, Baty Florent, Rassouli Frank, Kleiner Rebekka L, Kohler Philipp, Brutsche Martin H, von Mering Christian
Abstract excerpt
BACKGROUND: Cystic fibrosis (CF) is a life-threatening genetic disorder, characterized by chronic microbial lung infections due to abnormally viscous mucus secretions within airways. The clinical management of CF typically involves regular respiratory-tract cultures in order to identify pathogens and to guide treatment. However, culture-based methods can miss atypical or slow-growing microbes. Furthermore, the...
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