Article

Proteomic Discovery of Urinary Myoglobin as a Noninvasive Biomarker for PROCHOB caused by <i>CUBN</i> Variants

2026-04-01

Abstract excerpt

Chronic benign proteinuria (PROCHOB)—caused by biallelic pathogenic variants in CUBN —presents in childhood as isolated, asymptomatic tubular proteinuria with preserved long-term kidney function. Because its clinical presentation closely mimics early stage glomerular diseases with moderate proteinuria and without increased urinary β2-microglobulin (uBMG) and α1-microglobulin, numerous patients undergo unnecessary...

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Literature Corpus work: f61f3ea3-a4c7-57ff-8e1b-d77b7c0d0aac
DOI: 10.64898/2026.03.26.26349155

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