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Article

Proteinuria in Dent disease: a review of the literature.

Pediatric nephrology (Berlin, Germany) - 1 Oct 2017

van Berkel Youri, Ludwig Michael, van Wijk Joanna A E, Bökenkamp Arend

Abstract excerpt

BACKGROUND: Dent disease is a rare X-linked recessive proximal tubulopathy caused by mutations in CLCN5 (Dent-1) or OCRL (Dent-2). As a rule, total protein excretion (TPE) is low in tubular proteinuria compared with glomerular disease. Several authors have reported nephrotic-range proteinuria (NP) and glomerulosclerosis in Dent disease. Therefore, we aimed to analyze protein excretion in patients with documented...

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Source

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Identifiers

PMID: 27757584
DOI: 10.1007/s00467-016-3499-x
PMCID: PMC5579149

Genes

CLCN5
OCRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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