Article

Integrated single-cell functional and molecular profiling of extracellular vesicle secretion in metastatic breast cancer

2022-08-15

Abstract excerpt

Extracellular vesicles (EVs) regulate the tumor microenvironment by facilitating transport of biomolecular cargo including RNA, protein, and metabolites. The biological effects of EV-mediated transport have been studied using supra-physiological concentrations of EVs, but the cells that are responsible for EV secretion and the mechanisms that support EV secretion are not well characterized. We developed an integra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f589cab8-25f3-54ee-bb7e-c45e46254cda
DOI: 10.1101/2022.08.13.503860

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated single-cell functional and molecular profiling of extracellular vesicle secretion in metastatic breast cancerDOI 10.1101/2022.08.13.503860Read

Extracellular vesicle heterogeneity through the lens of multiomicsSemantic proximity Read

Multiplexed Profiling of Single-cell Extracellular Vesicles SecretionSemantic proximity Read

Exploiting gene expression profiles of circulating extracellular vesicles for breast cancer detectionSemantic proximity Read

Characterization of extracellular vesicle-associated DNA and proteins derived from organotropic metastatic breast cancer cellsSemantic proximity Read

Monitoring of single extracellular vesicle heterogeneity in cancer progression and therapySemantic proximity Read

Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosisSemantic proximity Read

Heterogeneity of Extracellular Vesicles and Particles: Molecular Voxels in the Blood Borne "Hologram" of Organ Function, Disfunction and Cancer.Semantic proximity Read

Membrane Sensing Peptides -Enhanced SiMoA Platform for the Detection of HER2 on Extracellular Vesicles in Metastatic Breast Cancer PatientsSemantic proximity Read

Predicting cell type-specific extracellular vesicle biology using an organism-wide single cell transcriptomic atlas – insights from the <i>Tabula Muris</i>Semantic proximity Read

Multiplexed Profiling of Single Extracellular VesiclesSemantic proximity Read

Microfluidic Replication and Phenotypic Profiling of Extracellular Vesicles from the Tumor Microenvironment Using Dual-Switch Aptamer Logic Gates.Semantic proximity Read

Extracellular vesicles as cancer liquid biopsies: from discovery, validation, to clinical applicationSemantic proximity Read