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Evolutionary Mismatch in Generation X Women: An Integrated Model of Midlife Hormonal, Metabolic and Cognitive Dysfunction

2026-04-23

Abstract excerpt

Chronic stress, circadian disruption, sedentary behavior, industrialized diets and disturbances in the gut microbiome have created an evolutionary mismatch between ancestral physiology and the modern environment. Generation X (Gen X) women (born between 1965–1980) are the first cohort to enter midlife having lived their entire adult lives within these conditions while also carrying distinct cohort-specific factors...

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Literature Corpus work
f4c37d8d-8fb0-5f2e-bf60-2d42fd54294b
DOI
10.20944/preprints202604.1667.v1
Open publication

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