Article

Novel Biallelic TLE6 Variants Induce Preimplantation Embryonic Lethality That Cannot be Rescued by IVF or ICSI

2021-01-08

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Preimplantation embryonic lethality is a rare cause of primary female infertility. Transducin-like enhancer of split 6 (<italic>TLE6</italic>) is a maternal effect gene which encodes a component of the subcortical maternal complex located in the oocytes and early embryos. It has been reported that biallelic variants in <italic>TLE6</italic> can lead to preimplan...

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Literature Corpus work: f4c26229-d7ba-53f2-81d9-0c1278c69eab
DOI: 10.21203/rs.3.rs-140374/v1

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