Article

Diversification of Transcription Factor NF-κB in Protists

2021-03-15

Abstract excerpt

In this report, we investigate the evolution of transcription factor NF-κB by examining its structure, activity, and regulation in two protists using phylogenetic, cellular, and biochemical techniques. In Capsaspora owczarzaki ( Co ), we find that full-length NF-κB has an N-terminal DNA-binding domain and a C-terminal Ankyrin (ANK) repeat inhibitory domain, and its DNA-binding activity is more similar to metazoa...

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Literature Corpus work: f480f5d6-8da1-5ae0-9831-75598027eea4
DOI: 10.1101/2021.03.15.435342

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