Article

Estimate of the mutation rate in the endangered Devils Hole pupfish provides equivocal support for the drift-barrier hypothesis at an outlying extreme

2026-01-12

Abstract excerpt

Mutation rates vary by orders of magnitude across eukaryotes. The drift-barrier hypothesis proposes that drift overwhelms selection for lower mutation rates in small populations, leading to higher mutation rates over time due to the gradual accumulation of mutator alleles. Here, we test this hypothesis in one of the smallest long-term isolated populations in the world, the endangered Devils Hole pupfish ( Cyprino...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3ed3226-352f-5526-a7e3-9d7ea6e3e31d
DOI: 10.64898/2026.01.11.698928

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Estimate of the mutation rate in the endangered Devils Hole pupfish provides equivocal support for the drift-barrier hypothesis at an outlying extremeDOI 10.64898/2026.01.11.698928Read

Severe inbreeding, increased mutation load and gene loss-of-function in the critically endangered Devils Hole pupfish.Semantic proximity Read

Severe inbreeding and gene loss in the historical and extant population of the critically endangered Devils Hole pupfishSemantic proximity Read

Experimental estimates of germline mutation rate in eukaryotes: a phylogenetic meta-analysisSemantic proximity Read

Germline mutation rate in guppies ( Poecilia retuculata ) confirms a low mutation rate in teleost fishesSemantic proximity Read

Direct measurement of the mutation rate and its evolutionary consequences in a critically endangered molluskSemantic proximity Read

The mutation landscape of Daphnia obtusa reveals evolutionary forces shaping genome stability.Semantic proximity Read

Genes shielded, repeats exposed: mutation bias in the midge Chironomus riparius.Semantic proximity Read

High germline mutation rates but not extreme population size outbreaks influence genetic diversity in crown-of-thorns sea starsSemantic proximity Read

A new era of mutation rate analyses: Concepts and methods.Semantic proximity Read

Validation of machine learning approach for direct mutation rate estimation.Semantic proximity Read

Germline <i>de novo</i> mutation rate of the highly heterozygous amphioxus genomeSemantic proximity Read

What sets the mutation rate of a cell type in an animal species?Semantic proximity Read