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The mutation landscape of Daphnia obtusa reveals evolutionary forces shaping genome stability.

Molecular biology and evolution - 2 Feb 2026

Deng Ruyun, Guo Feng, Fan Fei, Wei Wen, Pfrender Michael E, Dudycha Jeff L, Lynch Michael, Ye Zhiqiang

Abstract excerpt

Spontaneous mutations are the primary source of genetic variation and play a central role in shaping evolutionary processes. To investigate mutational dynamics in Daphnia obtusa, we generated a chromosome-level genome assembly spanning 129.4 Mb across 12 chromosomes, encompassing 15,321 predicted protein-coding genes. Leveraging whole-genome sequencing of eight mutation-accumulation (MA) lines propagated for an...

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PMID: 41656912
DOI: 10.1093/molbev/msag037
PMCID: PMC12926508

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