Back to search

Article

The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis

2020-06-09

Abstract excerpt

Most patients with COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), display neurological symptoms, and respiratory failure in certain cases could be of extra-pulmonary origin. Hypothalamic neural circuits play key roles in sex differences, diabetes, hypertension, obesity and aging, all risk factors for severe COVID-19, besides being connected to olfactory/gustative and brainstem ca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f2fa7266-171f-5f7d-a7db-d4dcae5aa3ec
DOI
10.1101/2020.06.08.139329
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesisDOI 10.1101/2020.06.08.139329
ACE2 Receptor and TMPRSS2 Protein Expression Patterns in the Human Brainstem Reveal Anatomical Regions Potentially Vulnerable to SARS-CoV-2 InfectionSemantic proximity
SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepitheliumSemantic proximity
SARS-CoV-2 Infectivity and Neurological Targets in the Brain.Semantic proximity
Identification of Novel Hypothalamic MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating ACE2 and TMPRSS2 Expression: An In Silico AnalysisSemantic proximity
Spatial transcriptomics identifies the molecular and disease landscapes of adult human hypothalamusSemantic proximity
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmiaSemantic proximity
Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic MechanismsSemantic proximity
The hypothalamus for whole-body physiology: from metabolism to agingSemantic proximity
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disordersSemantic proximity
Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic miceSemantic proximity
Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamusSemantic proximity
Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic modelSemantic proximity
Select a neighboring publication to make it the new centre.