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<i>In vitro</i> and <i>in vivo</i> venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by <i>Dispholidus typus</i>

2022-01-07

Abstract excerpt

Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom induced consumption coagulopathy, whereby highly abundant prothrombin-activating snake venom metalloproteinases (SVMPs) consume clotting factors and deplete fibrinogen. The only available treatment for D. typus envenoming is the monovalent SAIMR Boomslang antivenom. T...

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Literature Corpus work
f2d5996f-3017-5965-a8f9-66d8c2e37af1
DOI
10.1101/2022.01.07.475313
Open publication

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